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Taxol is a novel antineoplastic agent that has demonstrated impressive clinical activity in breast,ovarian,lung,and head and neck cancers.This broad antitumor activity of taxol in cisplatin-sensitive tumors suggests that the combination of taxol and cisplatin may become one of the most commonly used taxol-based chemotherapeutic regimen in the treatment of solid tumors.We conclude that sensory-motor neuropathy is a frequent dose- dependent toxicity of combined cisplatin and taxol use.Peripheral neuropathy is likely to become the major dose-limiting toxicity of taxol- cisplatin combination chemotherapy when higher doses of these agents are administered with granulocytecolony stimulating factor. |
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